D: CYP1A2

Wed, 29 Apr 2026 18:03:39 +0000

# Understanding D: CYP1A2 – Key Roles in Metabolism, Health, and Genetic Variability D: CYP1A2 may sound like a technical term from the world of biochemistry, but its impact on human health—especially in drug metabolism and disease susceptibility—is profound and increasingly relevant today. If you’re exploring pharmacogenomics, personalized medicine, or simply curious about how your body processes certain medications, understanding CYP1A2 is essential. This article breaks down what CYP1A2 is, its role in metabolism, clinical significance, and how genetic variability influences individual responses to drugs and environmental toxins. ## What is CYP1A2? CYP1A2 (Cytochrome P450 family 1 subfamily A group 2) is an enzyme encoded by the CYP1A2 gene, part of the cytochrome P450 superfamily involved in metabolizing a wide range of endogenous and exogenous compounds. Primarily expressed in the liver, CYP1A2 catalyzes the oxidation of various substrates, including: