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Lymphoma & related disorders - Follicular lymphoma, nodal, usual variant
Lymphoma & related disorders - Follicular lymphoma, nodal, usual variant
Unusual morphologic patterns seen in cases of follicular lymphoma (FL) that do not represent biologically distinct variants of FL; may not be easily recognizable due to histopathologic.
Follicular lymphoma: follicular-usual follicular lymphoma-duodenal type in situ follicular B cell neoplasm pediatric type follicular lymphoma primary follicular lymphoma-testis unusual morphologic patterns of.
Understanding the Context
Duodenal type follicular lymphoma is a variant of follicular lymphoma that is almost always diagnosed at a low stage and stays localized to the small intestine, unlike nodal follicular.
Mature T cell lymphoma with a T follicular helper phenotype, defined by the expression of CD4 and at least 2 (ideally 3) TFH markers, primarily involving lymph nodes
Follicular, diffuse or follicular and diffuse growth pattern Presence of monoclonal B cells in the right clinical and pathologic context can support a diagnosis of primary cutaneous follicle center.
Angioimmunoblastic T cell lymphoma is a nodal based, mature T cell lymphoma derived from CD4+ T follicular helper (TFH) cells admixed with a polymorphous infiltrate of reactive cells
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Key Insights
The lymphoma demonstrates a diffuse pattern and the lymphoma cells are intermediate sized. Lymphoma cells have irregular nuclear contours, relatively closed chromatin, inconspicuous.
In situ follicular neoplasia is a monoclonal proliferation of BCL2 positive B cells confined to follicle centers.
CD5 is a transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and some B lymphocytes (B1a).
